Med Chem Res

Afaf K. Elansary, Hanan H. Kadry, Eman

M Ahmed, ASM Sonousi

文献索引：Elansary, Afaf K.; Kadry, Hanan H.; Ahmed, Eman M.; Sonousi, Amr Sayed Motawi Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3327 - 3335

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摘要

Abstract In this study, a novel series of quinazolinone derivatives analogue to nitraquazone structure were synthesized. The compounds tested for their inhibitory activity against phosphodiesterase 4B revealed that compound 6d shows promising inhibitory activity comparable to that of Rolipram, whereas compounds 6a and 6c exhibited moderate inhibitory activity. Keywords Phosphodiesterase 4 (PDE4) inhibitors Á Quinazolinone Á ...