Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization

YM Choi-Sledeski, DG McGarry…

文献索引：Journal of Medicinal Chemistry, , vol. 42, # 18 p. 3572 - 3587

被引用次数: 44

摘要

... Journal of Medicinal Chemistry. ... Pennsylvania 19426-0107. J. Med. Chem. , 1999, 42 (18), pp 3572–3587. DOI: 10.1021/jm990041+. Publication Date (Web): August 17, 1999. Copyright © 1999 American Chemical Society. ...

93777-26-5

5-溴-2-氟苯甲醛

99725-12-9

2-氟-5-溴溴苄

Sulfonamidopyrrolidinone factor Xa inhibitors: potency and s...

[Choi-Sledeski, Yong Mi; McGarry, Daniel G.; Green, Daniel M.; Mason, Helen J.; Becker, Michael R.; Davis, Roderick S.; Ewing, William R.; Dankulich, William P.; Manetta, Vincent E.; Morris, Robert L.; Spada, Alfred P.; Cheney, Daniel L.; Brown, Karen D.; Colussi, Dennis J.; Valeria, Chu; Heran, Christopher L.; Morgan, Suzanne R.; Bentley, Ross G.; Leadley, Robert J.; Maignan, Sebastien; Guilloteau, Jean-Pierre; Dunwiddie, Christopher T.; Pauls, Henry W. Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3572 - 3587]