A Facile Route for Synthesis of (?)-Dinoprost,(?)-Carboprost and Its Analogs
…, MH Krishna, PM Rao, T Lakshmikumar…
文献索引：Shankar; Mohan, H. Rama; Prasad, U. Viplava; Krishna, M. Hari; Rao, P. Mareswar; Lakshmikumar; Subbaraju, Gottumukkala V. Asian Journal of Chemistry, 2013 , vol. 25, # 2 p. 913 - 920
Abstract A general synthetic approach was developed for (±)-dinoprost (1),(±)-carboprost (2) and their analogs (3-5) through a key intermediate (6). Compound 6 can be converted into the target compounds in two or three steps. Diastereomeric separation was accomplished easily for obtaining (±) dinoprost. Separation of diastereomers was difficult for (±) carboprost and their analogs. Key intermediate 6 was obtained, in turn, from (±)-corey lactone.
