2-Aryloxymethylmorpholine histamine H 3 antagonists
…, P Bonaventure, MA Feinstein, B Lord, KL Miller…
文献索引：Letavic, Michael A.; Keith, John M.; Ly, Kiev S.; Bonaventure, Pascal; Feinstein, Mark A.; Lord, Brian; Miller, Kirsten L.; Motley, S. Timothy; Nepomuceno, Diane; Sutton, Steven W.; Carruthers, Nicholas I. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 21 p. 5796 - 5799
The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H 3 antagonists is described. The new compounds are high affinity histamine H 3 ligands that penetrate the CNS and occupy the histamine H 3 receptor in rat brain. ... 2-Aryloxymethylmorpholines are potent histamine H 3 antagonists. ... Following the cloning of the human histamine H 3 receptor numerous pharmaceutical companies initiated drug discovery efforts designed to identify ...
