Abstract The asymmetric transfer hydrogenation of a series of halo-substituted aryl methyl ketones, including those substituted in both α-methyl and aryl rings, was studied for the preparation of chiral halohydrins. Up to 99.7% ee was obtained with 2-chloro-1-(2- chlorophenyl) ethanone as the substrate and Ru-CsDPEN as the catalyst in an HCOONa/H 2 O system.(R)-Clorprenaline, a drug used in the treatment of respiratory disorders, such ...
