Recognition of the minor groove of DNA by hairpin polyamides containing α-substituted-β-amino acids

PE Floreancig, SE Swalley, JW Trauger…

文献索引：Floreancig, Paul E.; Swalley, Susanne E.; Trauger, John W.; Dervan, Peter B. Journal of the American Chemical Society, 2000 , vol. 122, # 27 p. 6342 - 6350

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被引用次数: 61

摘要

Incorporation of the flexible amino acid β-alanine (β) into hairpin polyamides composed of N- methylpyrrole (Py) and N-methylimidazole (Im) amino acids is required for binding to DNA sequences longer than seven base pairs with high affinity and sequence selectivity. Pairing the α-substituted-β-amino acids (S)-isoserine (S Is),(R)-isoserine (R Is), β-aminoalanine (Aa), and α-fluoro-β-alanine (Fb) side-by-side with β in hairpin polyamides alters DNA ...