Bioorganic & medicinal chemistry letters

A solid-supported phosphine-free ruthenium alkylidene for olefin metathesis in methanol and water

SJ Connon, S Blechert

文献索引：Connon, Stephen J; Blechert, Siegfried Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 14 p. 1873 - 1876

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被引用次数: 148

摘要

The synthesis and olefin metathesis activity in protic solvents of 7, a phosphine-free ruthenium alkylidene bound to a hydrophilic solid support are reported. This heterogeneous catalyst promotes relatively efficient ring closing-and cross-metathesis reactions in both methanol and water. The potential utility of homogeneous catalyst 2 for olefin metathesis in methanol is also demonstrated.