L-. beta.-(2S, 4S)-and L-. alpha.-(2S, 4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships

HO Kim, RF Schinazi, K Shanmuganathan…

文献索引：Kim; Schinazi; Shanmuganathan; Jeong; Beach; Nampalli; Cannon; Chu Journal of Medicinal Chemistry, 1993 , vol. 36, # 5 p. 519 - 528

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被引用次数: 124

摘要

In order to study the structure-activity relationships of L-(~ S,~ S)- and~-(2S, 4R)-dioxolanyl nucleosides as potential anti-HIV agents, various enantiomerically pure L-(~ S,~ S)- and (2S, 4R)-dioxolanylpyrimidine and-purine nucleosides have been synthesized and evaluated against HIV-1 in human peripheral blood mononuclear (PBM) cells. The enantiomerically pure key intermediate 8 has been synthesized in sixsteps from 1, 6-anhydro-8-~-gulose ( ...