Tetrahedron letters

An extremely short synthesis of benzoylpyrrole-type calcium channel activators

CR Dalton, JM Kane, D Rampe

文献索引：Dalton, Christopher R.; Kane, John M.; Rampe, David Tetrahedron Letters, 1992 , vol. 33, # 39 p. 5713 - 5716

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被引用次数: 14

摘要

Abstract Friedel-Crafts acylation of methyl 2, 5-dimethylpyrrole-3-carboxylate with 2- chloromethylbenzoyl chloride generated the corresponding 4-(2-chloromethylbenzoyl) pyrrole which was reacted in situ with benzene and aluminum chloride to yield the novel calcium channel activator FPL 64176.