A concise first total synthesis of narceine imide

…, A Couture, E Deniau, P Grandclaudon

文献索引：Lamblin, Marc; Couture, Axel; Deniau, Eric; Grandclaudon, Pierre Organic and Biomolecular Chemistry, 2007 , vol. 5, # 9 p. 1466 - 1471

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被引用次数: 37

摘要

A concise and efficient total synthesis of alkaloid narceine imide is disclosed. The key steps are based upon the sequential construction of the isoindolinone template followed by metalation and coupling with an isoquinolinium salt. Subsequent E1cb elimination enables the creation of the arylmethylene unit with the concomitant formation of the dimethylaminoethyl chain and ultimate deprotection completes the synthesis of the natural ...