Chemo-enzymatic synthesis of (R)-and (S)-3, 4-dichlorophenylbutanolide intermediate in the synthesis of sertraline

C Barbieri, E Caruso, P D'Arrigo, GP Fantoni…

文献索引：Barbieri, Cinzia; Caruso, Enrico; D'Arrigo, Paola; Pedrocchi Fantoni, Giuseppe; Servi, Stefano Tetrahedron Asymmetry, 1999 , vol. 10, # 20 p. 3931 - 3937

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被引用次数: 24

摘要

3, 4-Dichlorophenacylchloride was reduced with whole cell biocatalysts to give the (R)-or (S)- chlorohydrine in high yields and good to high enantiomeric excess. Yields and enantiomeric purity of the (S)-enantiomer were increased to 95 and> 98%, respectively, using growing cells from Geotrichum candidum (CBS 233.76) in the presence of hydrophobic adsorbing resins at 4 g/l. The latter compound was transformed into (R)-3, 4- ...