Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

RC Young, RC Mitchell, TH Brown…

文献索引：Journal of Medicinal Chemistry, , vol. 31, # 3 p. 656 - 671

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被引用次数: 472

摘要

... (24) Fujisawa Pharmaceutical Co. Ltd. Jpn. ... Table I. Physicochemical Properties and Brain-Penetration Data for Three Hz Antagonists and Three Compounds That Readily Cross the Blood-Brain Barrier Journal of Medicinal Chemistry, 1988, Vol. 31, No. 3 659 log pn ...