Metabolism of proxodolol studied by methods of TLC, mass spectrometry, and NMR

…, KF Turchin, IV Golovanova, SM Vinogradova…

文献索引：Anisimova; Turchin; Golovanova; Vinogradova; Yuzhakov; Mashkovskii; Pleshkova; Sheinker Pharmaceutical Chemistry Journal, 1997 , vol. 31, # 5 p. 224 - 228

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摘要

Experiments with animals. The study of proxodolol metabolism was performed on white mongrel intact rats weighing 200-300 g. Each test was carried out in a group of 8-10 animals. One day before testing, the animals were deprived of feeding and received only water. The test preparations were introduced peromlly at a dose of 100 mg/kg in the form of an aqueous solution. Samples of urine were taken within 0-4, 4-7, and 7-24 h intervals ...