A novel series of 2, 5-disubstituted 1, 3, 4-thiadiazoles as potential anticonvulsant agent

…, CK Behera, RS Pawar, PK Singour, MD Kharya

文献索引：Rajak, Harish; Behera, Chinmay K.; Pawar, Rajesh S.; Singour, Pradeep K.; Kharya, Murli Dhar Chinese Chemical Letters, 2010 , vol. 21, # 10 p. 1149 - 1152

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被引用次数: 16

摘要

In pursuit for better antiepileptic drug and the importance of semicarbazones and 2, 5- disubstituted 1, 3, 4-thiadiazoles as anticonvulsant pharmacophore, a series of novel N-({5- [(6-methyl-1-benzofuran-3-yl) methyl]-1, 3, 4-thiadiazol-2-yl} carbamothioyl)-2/3/4- substitutedbenzamide were designed, synthesized and evaluated for their anticonvulsant activity. The findings of the present studies confirmed that the pharmacophore model with ...