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Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono-and disubstituted analogues and pharmacology of the orally active …

N Murugesan, Z Gu, PD Stein, S Bisaha…

文献索引:Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5198 - 5218

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被引用次数: 40

摘要

... Journal of Medicinal Chemistry. ... Chemistry. The sulfonamides 3a−f and 6 (Table 1) were prepared by condensation of the arylsulfonyl chlorides with the commercially available 3,4-dimethyl-5-isoxazolamine in pyridine. ...