Synthesis and structure–activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint

S Hudson, M Kiankarimi, W Eccles, YS Mostofi…

文献索引：Hudson, Sarah; Kiankarimi, Mehrak; Eccles, Wendy; Mostofi, Yalda S.; Genicot, Marc J.; Dwight, Wesley; Fleck, Beth A.; Gogas, Kathleen; Wade, Warren S. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 16 p. 4495 - 4498

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被引用次数: 21

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The design, synthesis and SAR of a series of heterocyclic ring-constrained norepinephrine reuptake inhibitors are described. As racemates, the best compounds compare favorably with atomoxetine (IC 50 's < 10 nM) in potency at the transporter. ... A series of heterocyclic ...