Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues

S Saha, CVR Reddy, S Xu, S Sankar, N Neamati…

文献索引：Saha, Sanjay; Reddy, Ch. Venkata Ramana; Xu, Shili; Sankar, Saranya; Neamati, Nouri; Patro, Balaram Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5135 - 5139

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被引用次数: 4

摘要

Abstract The synthesis of several analogues of ma'edamines A and B are reported. The synthesized compounds were tested on hormone receptor positive and HER2 positive breast cancer cell lines, by MTT assay. MED-114, 115, 117, 119, 120, 124, 128 and 131 were found to be equally active as Lapatinib on HER2+ ve cell line SKBR3.