1,5-Naphthyridines, nitrogen-containing heterocycles, are interesting molecules because they feature several favorable characteristics for drug development. [ 1 1. (a) Bemis , GW ; Murcko , MA The properties of known drugs. 1. Molecular frameworks . J. Med. Chem. 1996 , 39 , 2887 – 2893 ; (b) Waterbeemd , H. ; Smith , DA ; Beaumont , K. ; Walker , DK Property-based design: Optimization of drug absorption and pharmacokinetics . J. Med. Chem. 2001 , 44 , ...