Regioselective ring opening of thiomalic acid anhydrides by carbon nucleophiles. Synthesis and X-ray structure elucidation of novel thiophenone derivatives
…, V McKee, J Markopoulos, O Igglessi-Markopoulou
文献索引：Kikionis, Stefanos; McKee, Vickie; Markopoulos, John; Igglessi-Markopoulou, Olga Tetrahedron, 2009 , vol. 65, # 18 p. 3711 - 3716
Novel and promising thiophenone derivatives were synthesised by regioselective ring opening of activated thiomalic acid anhydrides, with a variety of active methylene nucleophiles via a C-acylation/cyclisation process involving an S–C bond formation. This regioselective approach could be moreover established by X-ray diffraction structure analysis. The thiolactone ring can act as valuable synthetic scaffold for the preparation of ...
