Simple, Improved Synthesis of 3-Azaspiro [5, 5] undecane-2, 4-dione, the Precursor of Gabapentin

MKP Divi, BLM Rao, AN Rao

文献索引：Divi, Murali Krishna Prasad; Rao, Bandarupalli Leela Maheswara; Rao, Aswatha Narayana Organic Preparations and Procedures International, 2013 , vol. 45, # 6 p. 504 - 506

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摘要

Earlier, compound 2 had been prepared by heating a mixture of 1, 1-cyclohexane–diacetic acid (1) and ammonium acetate in acetic anhydride. 1 Acetic anhydride is a controlled chemical listed in the UN convention against illicit traffic in narcotic drugs and psychotropic substances. 4 As a result of this convention, the availability of acetic anhydride is severely restricted and its use on an industrial scale is becoming difficult. Handley et al. had ...