Synthesis of (Z)-2-[(Z)-3-Alkylideneisobenzofuran-1 (3H)-ylidene] acetic Acid Derivatives by Sequential Coupling-Cyclization between 3-(2-Iodophenyl)-3- …
Abstract 3-(2-Iodophenyl)-3-oxopropanoic acid derivatives reacted efficiently with various terminal alkynes in the presence of catalytic amounts of dichlorobis (triphenylphosphine) palladium and copper (I) iodide and two molar amounts of triethylamine in N, N- dimethylformamide at room temperature to afford the corresponding (Z)-2-[(Z)-3- alkylideneisobenzofuran-1 (3H)-ylidene] acetic acid derivatives in reasonable yields.
