2, 2, 4, 6, 7??Pentamethyl??2, 3??dihydrobenzofuran??5??methyl (Pbfm) as an Alternative to the Trityl Group for the Side??Chain Protection of Cysteine and Asparagine/ …

…, JM Bofill, E Nicolas, F Albericio

文献索引：Garcia, Oscar; Bofill, Josep M.; Nicolas, Ernesto; Albericio, Fernando European Journal of Organic Chemistry, 2010 , # 19 p. 3631 - 3640

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被引用次数: 5

摘要

Abstract The benzyl derivative of the Pbf group, which is the most commonly used side-chain protecting group for Arg, has been proposed for the protection of the side chains of Cys, Asp, and Glu. In the three cases, the new protecting group (Pbfm) was removed with a high concentration of TFA during the cleavage and global deprotection step. In addition, the Pbfm group can be removed from the Cys residue by using very dilute TFA solutions. ...