Synthesis

Chemoselective Arylsulfenylation of 2-Aminoimidazol [1, 2-a] pyridines by Phenyliodine (III) Bis (trifluoroacetate)(PIFA)

C Hamdouchi, C Sanchez, J Ezquerra

文献索引：Hamdouchi, Chafiq; Sanchez, Concha; Ezquerra, Jesus Synthesis, 1998 , # 6 p. 867 - 872

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被引用次数: 26

摘要

Abstract: A series of 2-(trifluoroacetamido) imidazo [1, 2-a]-pyridines was prepared and treated with phenyliodine (III) bis (trifluoroacetate)(PIFA) in the presence of a variety of thiols leading chemoselectively to the corresponding 3-sulfides. Exposure of these adducts to silica gel in MeOH/CH2Cl2 provides a convenient method for the cleavage of the trifluoroacetamide group. Key words: chemoselective sulfenylation, phenyliodine (III) bis ( ...