Asymmetric microbial reduction of prochiral 2, 2,-disubstituted cycloalkanediones

…, H Mazdiyasni, PG Grothaus

文献索引：Brooks, Dee W.; Mazdiyasni, Hormoz; Grothaus, Paul G. Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3223 - 3232

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被引用次数: 89

摘要

Asymmetric microbial reduction of a series of 2, 2-disubstituted 1, 3-cycloalkanediones with bakers' yeast was examined as an example of an enzyme-catalyzed distinction of a substrate containing two trigonal carbonyl centers with stereoheterotropic faces and one prochiral tetrahedral carbon center where monoreduction generates two chiral centers. Synthetically useful yeast-mediated reductions were achieved for cyclopentanoid and ...