Orally bioavailable 6-chloro-7-methoxy-4 (1 H)-quinolones efficacious against multiple stages of plasmodium
…, JN Burrows, DE Kyle, R Manetsch
文献索引：Cross, R. Matthew; Namelikonda, Niranjan K.; Mutka, Tina S.; Luong, Lisa; Kyle, Dennis E.; Manetsch, Roman Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8321 - 8327
The continued proliferation of malaria throughout temperate and tropical regions of the world has promoted a push for more efficacious treatments to combat the disease. Unfortunately, more recent remedies such as artemisinin combination therapies have been rendered less effective due to developing parasite resistance, and new drugs are required that target the parasite in the liver to support the disease elimination efforts. Research was initiated to ...
