Tetrahedron Letters

Copper-promoted iodovinylation of amides: synthesis of β-functionalized enamides

GF Sanapo, B Daoust

文献索引：Sanapo, Gabriel F.; Daoust, Benoit Tetrahedron Letters, 2008 , vol. 49, # 26 p. 4196 - 4199

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被引用次数: 15

摘要

We studied the addition of nitrogen radicals to ynol ethers in order to form β-functionalized enamides. Poor yields are reported. On the other hand, we observed that copper coupling between 1, 2-diiodoethene and various amides leads to β-functionalized enamides in high yields with complete stereocontrol.