Synthesis and antitumor activity of platinum (II) complexes containing substituted ethylenediamine ligands

…, U Holzinger, B Treittinger, H Schönenberger

文献索引：Brunner, Henri; Hankofer, Peter; Holzinger, Ulrich; Treittinger, Barbara; Schoenenberger, Helmut European Journal of Medicinal Chemistry, 1990 , vol. 25, # 1 p. 35 - 44

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被引用次数: 36

摘要

Abstract The synthesis of substituted ethylenediamines, their reactions with K 2 PtCl 4 to give the dichloroplatinum (II) complexes, and the exchange of the chloro ligands for other leaving groups are described. The new compounds have been tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the CD 2 F 1-mouse. In the ...