New one-pot, efficient, and regioselective method for the synthesis of 3-Trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs

HG Bonacorso, MS Correa, LMF Porte, EP Pittaluga…

文献索引：Bonacorso, Helio G.; Correa, Michele S.; Porte, Liliane M.F.; Pittaluga, Everton P.; Zanatta, Nilo; Martins, Marcos A.P. Tetrahedron Letters, 2012 , vol. 53, # 41 p. 5488 - 5491

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被引用次数: 12

摘要

An efficient and regioselective procedure for the synthesis of a series of alkyl (aryl/heteroaryl) substituted 3-trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs, from the cyclocondensation reactions of 4-alkoxy-1, 1, 1-trihaloalk-3-en-2-ones [CX3C (O) CR2= CR1 (OMe/OEt), where R1= H, Me, Ph, 2-Furyl; R2= H; R1-R2=-C4H8-and X= F, Cl] and 1-phenylsemicarbazide in an acidified alcoholic medium (R3OH/H2SO4), ...