New Rev-export inhibitor from Alpinia galanga and structure–activity relationship

…, M Kaneko, Y Ye, M Yoshida, M Yoshikawa…

文献索引：Tamura, Satoru; Shiomi, Atsushi; Kaneko, Masafumi; Ye, Ying; Yoshida, Minoru; Yoshikawa, Masayuki; Kimura, Tominori; Kobayashi, Motomasa; Murakami, Nobutoshi Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 9 p. 2555 - 2557

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被引用次数: 24

摘要

Bioassay-guided separation by use of the fission yeast expressing NES of Rev, an HIV-1 viral regulatory protein, disclosed 1′-acetoxychavicol acetate (ACA, 1) as a new inhibitor for nuclear export of Rev from the roots of Alpinia galanga. Both analysis for mechanism of action with biotinylated probe (2) and several synthesized analogs established crucial portions in 1 for Rev-export inhibitory activity.