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Tetrahedron letters

A novel method for the highly efficient synthesis of 1, 2-benzisoxazoles under neutral conditions using the Ph 3 P/DDQ system

N Iranpoor, H Firouzabadi, N Nowrouzi

文献索引:Iranpoor, Nasser; Firouzabadi, Habib; Nowrouzi, Najmeh Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8247 - 8250

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被引用次数: 30

摘要

Isoxazoline ring systems are an important class of nitrogen–oxygen heterocycles with many synthetic applications as structural units of many molecules of biological interest that has made them useful intermediates in medicinal chemistry. 1 Due to their biological activities, they have been the subject of extensive experimental studies 2 and many synthetic methods have been employed in the synthesis of these compounds including reactions of 2-hydroxy aryl aldoximes and ...