Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor α agonists

N Faucher, P Martres, A Laroze, O Pineau…

文献索引：Faucher, Nicolas; Martres, Paul; Laroze, Alain; Pineau, Olivier; Potvain, Florent; Grillot, Didier Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 710 - 715

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被引用次数: 8

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Starting from the structure of 5, a two-step strategy was applied to identify a new generation of trifluoromethane sulfonamides as potent PPARα agonists. Synthesis, in vitro and in vivo evaluation of the most potent compound are reported. ... Starting from the structure of 5, a two-step strategy was ...