6-Chloro-and 6-bromo-substituted steroids in the Suzuki-Miyaura cross-coupling reaction. A convenient route to potential aromatase inhibitors

…, PA Donez, GA Skryabin, IP Beletskaya

文献索引：Lukashev, Nikolay V.; Latyshev, Gennadij V.; Donez, Pavel A.; Skryabin, George A.; Beletskaya, Irina P. Synthesis, 2006 , # 3 p. 533 - 539

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被引用次数: 11

摘要

Abstract Chlorine at an sp 2-carbon in steroids has been shown to be reactive in Suzuki- Miyaura cross-coupling reactions with either Ni or Pd catalysts. The coupling of analogous 6- bromo derivatives has also been demonstrated to be applicable to a wider scope of substrates. The Suzuki-Miyaura arylation of 6-bromo-Δ 3, 5-steroid enol ethers with subsequent hydrolysis is a useful route to 6-arylated steroids bearing aryl at a saturated ...