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Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition

M Sodeoka, R Sampe, S Kojima, Y Baba…

文献索引:Journal of Medicinal Chemistry, , vol. 44, # 20 p. 3216 - 3222

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被引用次数: 100

摘要

... Journal of Medicinal Chemistry. ... Chemistry. We have already reported an asymmetric synthesis of RK-682 (1), its enantiomer (ent-1), and its side chain analogues 2 and 3, as well as the determination of their absolute stereochemistry. ...