A facile synthesis of novel chiral phosphonoacetates bearing a stereogenic phosphorus atom

…, E Kujime, Y Takemoto, M Shiro, Y Nagao

文献索引：Sano, Shigeki; Kujime, Eiko; Takemoto, Yuka; Shiro, Motoo; Nagao, Yoshimitsu Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 1 p. 131 - 134

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被引用次数: 5

摘要

Asymmetric Horner–Wadsworth–Emmons (HWE) reac- tion of prochiral cyclic ketones is of current interest.1—4) Sev- eral useful chiral HWE reagents such as phosphonates,5—9) phosphonoamides,10) and phosphonoamidates11) have been developed for the synthesis of olefins possessing an axis of chirality. However, most of these reagents are restricted to the compounds with non-stereogenic phosphorus atom. Al- though Motoyoshiya et al. reported ...