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Tetrahedron letters

Facile synthesis of 3, 4-dihydro-4, 4-dimethyl-2H-pyran-2-one via palladium catalyzed terminal oxidation of 3, 3-dimethyl-4-pentenoates

M Tanaka, H Urata, T Fuchikami

文献索引:Tanaka, Mariko; Urata, Hisao; Fuchikami, Takamasa Tetrahedron Letters, 1986 , vol. 27, # 27 p. 3165 - 3168

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被引用次数: 18

摘要

Abstract Selective terminal oxidation of 3, 3-dimethyl-4-pentenoates does occur under chloride-free Wacker conditions [Pd (OAc) 2/O 2] in AcOH to give 5-acetoxy-3, 3-dimethyl-4- pentenoates (7) and their analogues (2, 8) in good yields. Successive cyclization of 7 and 8 at vapor phase pyrolysis on SiO 2 affords 3, 4-dihydro-4, 4-dimethyl-2H-pyran-2-one (1).