Acyclic phosph (on) ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

…, KZ Hazleton, JM Mason, VL Schramm, PC Tyler

文献索引：Clinch, Keith; Crump, Douglas R.; Evans, Gary B.; Hazleton, Keith Z.; Mason, Jennifer M.; Schramm, Vern L.; Tyler, Peter C. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5629 - 5646

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被引用次数: 11

摘要

Abstract The pathogenic protozoa responsible for malaria lack enzymes for the de novo synthesis of purines and rely on purine salvage from the host. In Plasmodium falciparum (Pf), hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) converts hypoxanthine to inosine monophosphate and is essential for purine salvage making the enzyme an anti-malarial drug target. We have synthesized a number of simple acyclic aza ...