Synthesis of indoles using (N??arylaminomethyl) diphenylphosphine oxides

…, NLJM Broekhof, A van der Gen

文献索引：Zorgdrager, Jan; Broekhof, Nico L. J. M.; Gen, Arne van der Recueil des Travaux Chimiques des Pays-Bas, 1989 , vol. 108, # 12 p. 441 - 444

全文：HTML全文

被引用次数: 5

摘要

Abstract A new route for the synthesis of 1, 3-disubstituted indoles, based on (N- arylaminomethyl)-diphenylphosphine oxide (1) chemistry, is described. Adducts 2, obtained by addition of the carbanions from 1 to aldehydes, were treated with p-toluenesulfonic acid to form the desired indoles 4 in good yields, without isolation of the intermediate amino ketones 3.