Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase

SK Tipparaju, S Joyasawal, S Forrester…

文献索引：Tipparaju, Suresh K.; Joyasawal, Sipak; Forrester, Sara; Mulhearn, Debbie C.; Pegan, Scott; Johnson, Michael E.; Mesecar, Andrew D.; Kozikowski, Alan P. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 12 p. 3565 - 3569

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被引用次数: 33

摘要

Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR. ... Novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of enoyl-ACP reductase from Bacillus anthracis. ... Our structure optimization studies were based on predicted ...