Tetrahedron letters

Dephosphonylation of protected deoxynucleoside and oligodeoxynucleotide H-phosphonates

CB Reese, C Visintin

文献索引：Reese, Colin B.; Visintin, Cristina Tetrahedron Letters, 1999 , vol. 40, # 35 p. 6477 - 6480

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被引用次数: 4

摘要

The conversion of four 5′-O-(4, 4′-dimethoxytrityl)-2′-deoxyribonucleoside 3′-H- phosphonates 1 (B= 4, 5, 6 and 7) into their partially-protected nucleoside precursors 3 (B= 4, 5, 6 and 7, respectively) in good isolated yields is described. The procedure used is also suitable for the dephosphonylation of protected oligonucleotide H-phosphonate blocks.