Tetrahedron letters

Synthesis of A575C, a combined angiotensin converting enzyme inhibitor-beta adrenoceptor antagonist

GW Hardy, D Bull, HT Jones, G Mills, G Allan

文献索引：Hardy, George W.; Bull, Donald; Jones, Haydn T.; Mills, Gail; Allan, Geoffrey Tetrahedron Letters, 1988 , vol. 29, # 7 p. 799 - 802

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被引用次数: 9

摘要

As part of a programme of research with the objective of developing a novel antihypertensive agent, we have prepared a compound which has both Angiotensin Converting Enzyme (ACE) inhibitor and beta-blocking activities. Agents with these individual activities have become well established, independently, as effective and well tolerated anti- hypertensives in several forms of human hypertension. 1~ 2 A compound which ...