Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent 1

A Gangjee, J Yu, JJ McGuire, V Cody…

文献索引：Tomazic; Hynes Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 915 - 920

全文：HTML全文

被引用次数: 73

摘要

... Journal of Medicinal ... J. Med. Chem. ... 2,4-Diaminoquinazoline analogues as dual inhibitors were reported by Hynes et al. 21 with the suggestion that chemotherapeutic utility of such analogues would require that the inhibitory activity against DHFR be similar to that against TS. ...