Synthetic communications

Hypophosphorous Acid-Iodine: An Efficient and Mild Reagent for Cleavage of N–C Bond

G Meng, YP He, FE Chen

文献索引：Meng, Ge; He, Yan-Ping; Chen, Fen-Er Synthetic Communications, 2003 , vol. 33, # 15 p. 2593 - 2598

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被引用次数: 5

摘要

A mixture of hypophosphorous acid (H 3 PO 2 ) and iodine in acetic acid can selectively cleave the N-alkyl bond in a variety of substituted heterocylic compounds in good to excellent yields without any damage to amide bond present in the substrates. ... A mixture of hypophosphorous