Highly enantioselective recombinant thermoalkalophilic lipases from Geobacillus and Bacillus sp

…, L Hunter, N Ehya, MD Gibbs, PL Bergquist…

文献索引：Hutchins, Lauren M.; Hunter, Luke; Ehya, Noosha; Gibbs, Moreland D.; Bergquist, Peter L.; Hutton, Craig A. Tetrahedron Asymmetry, 2004 , vol. 15, # 18 p. 2975 - 2980

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被引用次数: 7

摘要

Thermoalkalophilic lipases from Geobacillus and Bacillus strains have been cloned and characterised, several of which show excellent activity and enantioselectivity towards various substrates. The hydrolysis of methyl 2-methyldecanoate proceeds to give (R)-2- methyldecanoic acid in good yield and> 99% enantiomeric excess (E> 200).