Bioorganic & medicinal chemistry letters

Functionalized acridin-9-yl phenylamines protected neuronal HT22 cells from glutamate-induced cell death by reducing intracellular levels of free radical species

T Nguyen, T Yang, ML Go

文献索引：Nguyen, Thuy; Yang, Tianming; Go, Mei-Lin Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 7 p. 1830 - 1838

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被引用次数: 4

摘要

Abstract The in vitro neuronal cell death model based on the HT22 mouse hippocampal cell model is a convenient means of identifying compounds that protect against oxidative glutamate toxicity which plays a role in the development of certain neurodegenerative diseases. Functionalized acridin-9-yl-phenylamines were found to protect HT22 cells from glutamate challenge at submicromolar concentrations. The Aryl 1-NH-Aryl 2 scaffold that ...