Improved procedure for Juliá–Colonna asymmetric epoxidation of α, β-unsaturated ketones: total synthesis of diltiazem and Taxol TM side-chain

…, BE Flowerdew, MP Jackson, R McCague…

文献索引：Adger, Brian M.; Barkley, James V.; Bergeron, Sophie; Cappi, Michael W.; Flowerdew, Benjamin E.; Jackson, Mark P.; McCague, Ray; Nugent, Thomas C.; Roberts, Stanley M. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 23 p. 3501 - 3507

全文：HTML全文

被引用次数: 148

摘要

Poly-L-leucine catalyses the asymmetric epoxidation of enones 1–6 efficiently in a non- aqueous medium to provide the epoxy ketones 7–12 (70–91% yield; 80 to 95% ee). The strategy was used to make diltiazem 16 and the TaxolTM side chain 23 in single enantiomer form.