Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin

SL Zhang, GLV Damu, L Zhang, RX Geng…

文献索引：Zhang, Shao-Lin; Damu, Guri L.V.; Zhang, Ling; Geng, Rong-Xia; Zhou, Cheng-He European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 164 - 175

全文：HTML全文

被引用次数: 56

摘要

A series of novel benzimidazole derivatives were synthesized and characterized by 1H NMR, 13C NMR, MS, IR and HRMS spectra. All the new compounds were screened for their antimicrobial activities in vitro by two-fold serial dilution technique. Bioactive assay manifested that the bis-benzimidazole derivative 11d and its hydrochloride 13b exhibited remarkable antimicrobial activities, which were comparable or even better than the ...