Synthesis of (±) Abyssinone I and related compounds: Their anti-oxidant and cytotoxic activities

…, BN Swamy, V Chandregowda, GC Reddy

文献索引：Rao, Gudapati Venkateswara; Swamy, Badrappa Narayana; Chandregowda, Venkateshappa; Reddy, G. Chandrasekara European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 2239 - 2245

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被引用次数: 38

摘要

An efficient and facile synthesis of naturally occurring prenylated flavonoids and their analogs have been described. Abyssinone I (9a) was prepared by condensing 2, 2-dimethyl chrom-3-en-6-carboxaldehyde (5a) with protected resacetophenone under phase transfer conditions followed by deprotection and cyclization. The influence of prenyl group on anti- oxidant and cytotoxic activities was studied. The presence of 3′-prenyl group as in 8c ...