A structure–permeability study of small drug-like molecules

T Fichert, M Yazdanian, JR Proudfoot

文献索引：Fichert, Thomas; Yazdanian, Mehran; Proudfoot, John R. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 719 - 722

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被引用次数: 55

摘要

A systematic structure–permeability relationship study on a set of small drug-like molecules with log D values in the range− 2.5 to 3 and carrying a diverse array of functionality reveals that the compounds with log D> 0 and< 3 are highly permeable. Surprisingly, several tetrazole derivatives were found to be substrates for efflux pump (s).