Synthesis of carbon-11 labeled fluorinated 2-arylbenzothiazoles as novel potential PET cancer imaging agents

…, KD Miller, GW Sledge, GD Hutchins, QH Zheng

文献索引：Wang, Min; Gao, Mingzhang; Mock, Bruce H.; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8599 - 8607

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被引用次数: 106

摘要

Fluorinated 2-arylbenzothiazoles are new potential antitumor drugs, which show potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Carbon-11 labeled fluorinated 2-arylbenzothiazoles may serve as novel probes for positron emission tomography (PET) to image tyrosine kinase in cancers. The preparation of 4-fluorinated 2- arylbenzothiazoles 4-fluoro-2-(3-benzloxy-4-methoxyphenyl) benzothiazole (6a) and 4- ...