Synthesis of acyclic nucleoside phosphonates as antiviral compounds

…, M Gütschow, K Eger, U Brinckmann

文献索引：Wormstadt; Brinckmann; Gutschow; Eger Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 5 p. 1187 - 1191

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被引用次数: 6

摘要

Abstract Reaction of 6-chloropyrimidines with diethyl [(2-aminoethoxy) methyl] phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5-substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (HSV-1 and HSV-2) and human immunodeficiency virus (HIV-1). Some compounds showed weak antiviral activity against HSV-1.